Currents from inside the Pharmacy Exercises and you may LearningAsma El-Magboub, Ian S

Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P

Physiological aim and pharmacology away from curcumin

Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the biggest component of the reddish color of turmeric, a keen Indian spice that is extracted from the fresh new rhizome of your warm plant Curcuma longa, and that belongs to the Zingiberaceae household members. Within this part, i discuss the pharmacological items away from curcumin and you will mention this new molecular bases of these issues. I up coming remark the confirmed and you may potential health-related uses of curcumin. Curcumin known over the years since the a restorative agent, however, the procedure regarding action are outlined. This new pharmacological outcomes of curcumin seem to be caused by an effective synergism off companies off poor biochemical relationships which have several physical aim from inside the interconnected signaling paths. These objectives become nutrients like cyclooxygenase, lipoxygenase and you may protein kinases, and transcription facts for example NF-?B, STAT and you can Nrf2. Modulation of those particles impacts downstream affectors that produce the latest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial circumstances off curcumin. This type of outcomes have been checked inside the scientific products regarding curcumin getting soreness and you can inflammatory ailment, disease, Alzheimer state, cardio sickness, and diabetes. The newest trials have used varying doses away from curcuminwith some other wavelengths and years, with the standard conclusion you to high dosage of curcumin during the quantity of grams are required to get therapeutic consequences. Read more

Curcumin: Synthesis, Emerging Role in Discomfort Administration and Wellness Effects

Guide Section Examples of plant-derived pharmaceuticals that have end up being the interest out-of persisted and you can great lookup and you can creativity notice have, thus far, come quite scarce. Shortly after years, the very last 2 decades was indeed described as a 100-flex rise in just how many scientific blogs typed a year you to try of importance toward use of curcumin from inside the biomedicine. Find out more

Framework, synthesis and you may physiological circumstances out of curcumin prodrugs

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some potential pharmacological effects and may keeps healing apps in a lot of condition claims, due to the fact talked about in detail in the previous chapter. Although not, the potential scientific effectiveness from curcumin is restricted from the their physicochemical characteristics out of terrible liquid solubility and you can instability, and that end in lowest bioavailability. Prodrugs off curcumin give a means to upgrade of one’s biopharmaceutical and pharmacokinetic services, and can even ensure it is exploitation of your own pharmacological effects of curcumin. In this part, i basic remark the fresh new physicochemical and you can pharmacokinetics regarding curcumin. We following define the appearance of curcumin prodrugs with enhanced liquids solubility and enhanced toxins balances which may be converted back to free curcumin up on bioactivation into the vivo. We high light present achievements of this type, having a concentrate on the design, synthesis and you will evaluation regarding prodrugs predicated on promoieties as well as amino acids, efas, nucleic acids, dicarboxylic acids, and you may polymeric materials such as for eastmeeteast krediter instance hyaluronic acidic and you may polyethylene glycol. So it part gets the reason behind optimization of the physicochemical and you can biopharmaceutical attributes while the physiological activities of curcumin prodrugs, to the mission having fun with of these curcumin derivatives for the medical apps. Read more